Invitrogen™ SCG5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103965

Catalog No. PIPA5103965

Description

Antibody detects endogenous levels of total SCG5.

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Specifications

• Antigen: SCG5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Scg5
• Gene Alias: 7B2; AI325031; C-terminal peptide; hypothetical protein MGC73132; LOC508224 protein; Neuroendocrine protein 7B2; neuronal endocrine protein; N-terminal peptide; P SGNE1; P7B2; pituitary polypeptide; prohormone convertase chaperone; SCG5; Secretogranin V; secretogranin V (7B2 protein); secretogranin-5; Secretory granule endocrine protein I; secretory granule neuroendocrine protein 1; secretory granule neuroendocrine protein 1, 7B2 protein; Secretory granule neuroendocrine, protein 1 (7B2 protein); secretory granule, neuroendocrine protein 1; secretory granule, neuroendocrine protein 1 (7B2 protein); SGNE1; Sgne-1; SgV; zgc:73132
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20394, 25719, 6447
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P05408, P12961, P27682
• Gene Symbols: Scg5
• Immunogen: A synthesized peptide derived from human SCG5(Accession P05408), corresponding to amino acid residues Q111-G161.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov