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Invitrogen™ SCIMP Monoclonal Antibody (NVL-07)
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Catalog No. PIMA528633
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100 μg
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Catalog No. Quantity
PIMA528633 100 μg
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Catalog No. PIMA528633 Supplier Invitrogen™ Supplier No. MA528633
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Description

Mouse Monoclonal Antibody

This antibody recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.

SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCIMP
Applications Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone NVL-07
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene SCIMP
Gene Accession No. Q6UWF3
Gene Alias A430084P05Rik; C17orf87; DTFT5783; SCIMP; SLP adapter and CSK-interacting membrane protein; SLP adaptor and CSK interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein; transmembrane protein C17orf87; transmembrane protein C17orf87 homolog; UNQ5783; UNQ5783/PRO16090
Gene Symbols SCIMP
Host Species Mouse
Immunogen Human SCIMP (intracellular region).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 388325
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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