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Invitrogen™ SCIMP Polyclonal Antibody
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Catalog No. PIPA552254
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100 μL
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PIPA552254 100 μL
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Catalog No. PIPA552254 Supplier Invitrogen™ Supplier No. PA552254
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RRGKKWEIAK PLKHKQVDEE KMYENVLNES PVQLPPLPPR NWPSLEDSSP QEAPSQPPAT YSLVNKVKNK KTVSIPSYIE PEDDYDDVEI PANTE Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 58%.

SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCIMP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SCIMP
Gene Accession No. Q6UWF3
Gene Alias A430084P05Rik; C17orf87; DTFT5783; SCIMP; SLP adapter and CSK-interacting membrane protein; SLP adaptor and CSK interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein; transmembrane protein C17orf87; transmembrane protein C17orf87 homolog; UNQ5783; UNQ5783/PRO16090
Gene Symbols SCIMP
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SCIMP. Recombinant protein control fragment (Product #RP-88833).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 388325
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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