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Tocris Bioscience™ SCIO 469 hydrochloride
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Quantity:
10 mg
50 mg
Description
SCIO 469 hydrochloride is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib -induced cytotoxicity against multiple myeloma cells.
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Specifications
Specifications
| Quantity | 50 mg |
| Formula Weight | 549.46 |
| Purity | >98% |
| Molecular Weight (g/mol) | 513.01 |
| Chemical Name or Material | SCIO 469 hydrochloride |
Safety and Handling
| Recommended Storage | Desiccate at +4°C. |
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