SCIO 469 hydrochloride, Tocris Bioscience™

Description

Selective p38 MAPK inhibitor

SCIO 469 hydrochloride is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib -induced cytotoxicity against multiple myeloma cells.

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Specifications

Chemical Identifiers

• CAS: 309913-83-5
• Molecular Formula: C27H30ClFN4O3
• Molecular Weight (g/mol): 513.01
• InChI Key: ZMELOYOKMZBMRB-DLBZAZTESA-N
• Synonym: talmapimod, scio-469, scios 469, scio 469, unii-b1e00kq6nt, b1e00kq6nt, scio 469 hydrochloride, 2-6-chloro-5-2r,5s-4-4-fluorobenzyl-2,5-dimethylpiperazin-1-yl carbonyl-1-methyl-1h-indol-3-yl-n,n-dimethyl-2-oxoacetamide, talmapimod usan, talmapimod usan:inn
• PubChem CID: 9871074
• IUPAC Name: 2-[6-chloro-5-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine-1-carbonyl]-1-methylindol-3-yl]-N,N-dimethyl-2-oxoacetamide
• SMILES: CC1CN(C(CN1C(=O)C2=C(C=C3C(=C2)C(=CN3C)C(=O)C(=O)N(C)C)Cl)C)CC4=CC=C(C=C4)F

• Quantity: 50 mg
• Formula Weight: 549.46
• Percent Purity: >98%
• Chemical Name or Material: SCIO 469 hydrochloride

Safety and Handling

Recommended Storage

Desiccate at +4°C.