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Invitrogen™ SCK Polyclonal Antibody
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Catalog No. PIPA5106744
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100 μL
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PIPA5106744 100 μL
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Catalog No. PIPA5106744 Supplier Invitrogen™ Supplier No. PA5106744
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SHC2.

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCK
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SHC2
Gene Accession No. O70142, P98077
Gene Alias 6720466E06; neuronal Shc adaptor homolog; protein Sck; Protein Sli; SCK; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; SHC2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; SLI; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2
Gene Symbols SHC2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SHC2(Accession P98077), corresponding to amino acid residues A297-P347.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25759, 314612
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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