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Invitrogen™ SCK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537052

Catalog No. PIPA537052


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Description

Description

This antibody detects endogenous protein at a molecular weight of 68 kDa. Purity is >95% by SDS-PAGE.

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SCK
Polyclonal
Unconjugated
SHC2
6720466E06; neuronal Shc adaptor homolog; protein Sck; Protein Sli; SCK; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; SHC2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; SLI; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2
Rabbit
Antigen affinity chromatography
RUO
216148, 25759, 314612
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.02% sodium azide; pH 7.2
O70142, P98077, Q8BMC3
SHC2
Synthetic peptide corresponding to amino acids 339-384 of human SCK.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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