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Invitrogen™ SCK Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA537052
Description
This antibody detects endogenous protein at a molecular weight of 68 kDa. Purity is >95% by SDS-PAGE.
Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.
Specifications
SCK | |
Polyclonal | |
Unconjugated | |
SHC2 | |
6720466E06; neuronal Shc adaptor homolog; protein Sck; Protein Sli; SCK; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; SHC2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; SLI; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
216148, 25759, 314612 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 0.02% sodium azide; pH 7.2 | |
O70142, P98077, Q8BMC3 | |
SHC2 | |
Synthetic peptide corresponding to amino acids 339-384 of human SCK. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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