Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ Sclerostin Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA546977

Catalog No. PIPA546977


Only null left
Add to Cart

Description

Description

In direct ELISAs, less than 2% cross-reactivity with recombinant human SOST is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Sclerostin, a glycoprotein predominantly secreted by osteocytes, is a member of the Cerberus/DAN family of putative BMP antagonists that functions as an endogenous regulator of the canonical Wnt signaling pathway and an inhibitory regulator of bone homeostasis. Although expressed nearly exclusively by osteocytes, sclerostin can also be found at significant levels elsewhere, such as bone, bone marrow, cartilage, the kidney, and the liver, and has also been shown to be produced by hypertrophic chondrocytes and cementocytes. Like DKK family members DKK-1 and DKK-4, sclerostin plays an important regulatory role in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL Receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. Sclerostin has also been shown to interact directly with LRP4 via its extracellular domain to facilitate inhibition of Wnt signaling, and can catabolically promote osteoclast activity by increasing osteocyte expression of RANKL. Sclerostin's critical involvement in the regulation of bone formation and resorption is emphasized by two bone dysplasia disorders, sclerosteosis and van Buchem disease (VBD), caused by rare autosomal recessive mutations that result in progressive bone overgrowth and hypermineralization due to markedly decreased sclerostin levels.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Sclerostin
Polyclonal
Unconjugated
SOST
5430411E23Rik; CDD; DAND6; sclerosteosis; sclerostin; SOST; SOST1; UNQ2976/PRO7455/PRO7476; VBCH
Goat
Antigen affinity chromatography
RUO
74499
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunohistochemistry (Frozen), Western Blot
0.2 mg/mL
PBS with 5% trehalose and No Preservative
Q99P68
SOST
Mouse myeloma cell line NS0-derived recombinant mouse SOST/Sclerostin Gln24-Tyr211.
100 μg
Primary
Mouse
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
Safety and Handling

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.