Invitrogen™ SCLY Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563172

Catalog No. PIPA563172

Description

Immunogen sequence: LYPMLFGGGQ ERNFRPGTEN TPMIAGLGKA AELVTQNCEA YEAHMRDVRD YLEERLEAEF GQKRIHLNS Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.

The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.

Specifications

• Antigen: SCLY
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Scly
• Gene Alias: 9830169H08; A930015N15Rik; hSCL; mSCL; SCL; SCLY; Scly1; Scly2; Selenocysteine lyase; selenocysteine lyase; Selenocysteine reductase; selenocysteine reductase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51540
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.08 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96I15
• Gene Symbols: Scly
• Immunogen: Recombinant protein corresponding to Human SCLY. Recombinant protein control fragment (Product #RP-103918).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov