SCN10A Mouse anti-Human, Mouse, Rat, Clone: S134-12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527663
DescriptionScn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Scn10a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn10a forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Scn10a also plays a role in neuropathic pain mechanisms. Structurally, members of Deg/ENaC superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1). Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2 and Sodium Channelopathy-Related Small Fiber Neuropathy.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|Q62968, Q6QIY3, Q9Y5Y9|
|mPN3, Peripheral nerve sodium channel 3, Pn3 (gene name), PN3, Scn10a, Sensory neuron sodium channel, Sns (gene name), SNS, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Voltage-gated sodium channel alpha subunit Nav1.8|
|20264, 29571, 6336|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Fusion protein amino acids 1724-1956 of rat Nav1.8|
|Human, Mouse, Rat|
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