SCN1A Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS1889R

Catalog No. 50-198-4265

Description

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Specifications

• Antigen: SCN1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Scn1a
• Gene Alias: 3-Feb; B230332M13; Brain Type I; CIN5; EIEE6; FEB3; FEB3A; FHM3; GEFS+2; GEFSP2; HBSC I; HBSCI; HH1; NAC1; Nav1.1; RBI; SCN1; Scn1a; SCN5A; SMEI; Sodium channel protein brain I subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type I subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type I alpha polypeptide; sodium channel, voltage gated, type I alpha subunit; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type I, alpha; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium voltage-gated channel alpha subunit 1; Voltage-gated sodium channel subunit alpha Nav1.1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 6323
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P35498
• Gene Symbols: Scn1a
• Immunogen: KLH conjugated synthetic peptide derived from human SCN1A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG