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Invitrogen™ SCN4B Polyclonal Antibody
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Catalog No. PIPA5110345
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100 μL
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PIPA5110345 100 μL
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Catalog No. PIPA5110345 Supplier Invitrogen™ Supplier No. PA5110345
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IDGIVKNDKS DPKVRVKDDD RITLEGSTKE KTNNISILLS DLEFSDTGRY TCFVRNPKEK DLNNSATIFL QVVDKLEKVD NTVTLIILAV VGGVIGLLVC ILLLKKLITF ILKKTREKKK ECLVSSSGND NTENGLPGSK AEEKPPTKV.

The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCN4B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 4.61 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SCN4B
Gene Accession No. Q7M729, Q7M730, Q8IWT1
Gene Alias ATFB17; Gm1471; LQT10; Navbeta4; Scn4b; sodium channel accessory subunit; sodium channel beta 4 subunit; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, type IV, beta polypeptide; sodium channel, voltage gated, type IV beta subunit; sodium channel, voltage-gated, type IV, beta subunit; sodium voltage-gated channel beta subunit 4; voltage gated sodium channel beta 4 subunit
Gene Symbols SCN4B
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 80-228 of mouse SCN4B (Q7M729).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 315611, 399548, 6330
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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