Invitrogen™ SCN4B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537419

Catalog No. PIPA537419

Description

This antibody detects endogenous protein at a molecular weight of 37 kDa. Purity is >95% by SDS-PAGE.

The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.

Specifications

• Antigen: SCN4B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCN4B
• Gene Alias: ATFB17; Gm1471; LQT10; Navbeta4; Scn4b; sodium channel accessory subunit; sodium channel beta 4 subunit; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, type IV, beta polypeptide; sodium channel, voltage gated, type IV beta subunit; sodium channel, voltage-gated, type IV, beta subunit; sodium voltage-gated channel beta subunit 4; voltage gated sodium channel beta 4 subunit
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 399548, 6330
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7M729, Q8IWT1
• Gene Symbols: SCN4B
• Immunogen: Recombinant full length human SCN4B.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG