SCN4B Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-6158	Proteintech Group Inc 554381AP150UL	150 μL

Description

The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation By similarity. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.

Specifications

• Antigen: SCN4B
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q7M729, Q8IWT1
• Gene ID (Entrez): 399548, 6330
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SCN4B

• Concentration: 0.39 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: SCN4B, Sodium channel subunit beta 4
• Gene Symbols: Scn4b
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody