Invitrogen™ SCN9A Polyclonal Antibody

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5109205	Invitrogen™ PA5109205	100 μL

Description

Positive Control: SH-SY5Y, A549, Hela, human placenta tissue, rat testis tissue.

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Specifications

• Antigen: SCN9A
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: SCN9A
• Gene Alias: ETHA; FEB3B; GEFSP7; hNaN; hNE Na; hNE-Na; HSAN2D; KIAA1356; Kiaa4197; MED; mKIAA4197; NAC1; NAC2; NAC3; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.6; Nav1.7; Nav1.8; Nav1.9; NE; NE NA; NENA; NE-NA; neuroendocrine sodium channel; Peripheral sodium channel 1; PN1; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; Scn2a; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; Scn9a; SFNP; SNS2; sodium channel 25; sodium channel protein type 9 subunit alpha; Sodium channel protein type IX subunit alpha; sodium channel, voltage gated, type IX alpha subunit; sodium channel, voltage-gated, type 9, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium voltage-gated channel alpha subunit 9; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel subunit alpha Nav1.7
• Gene Symbols: SCN9A
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Concentration: 1 mg/mL
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q15858
• Gene ID (Entrez): 6335
• Immunogen: Synthetic peptide within Human NaV17 aa 1,939-1,988.
• Product Type: Antibody