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SCN9A Polyclonal Antibody, Invitrogen™

Catalog No. PIPA566430
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PIPA566430 100 μL
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Catalog No. PIPA566430 Supplier Thermo Scientific Supplier No. PA566430

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RAYRRYRLRQN VKNISSIYIK DGDRDDDLLN KKDMAFDNVN ENSSP Highest antigen sequence identity to the following orthologs - mouse 91%, rat 89%.

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel′s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCN9A
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SCN9A
Gene Accession No. Q15858
Gene Alias SCN2A; NAC2; SCN2A1; SCN2A2; Nav1.1; NAC1; SCN1; SCN1A; Nav1.2; SCN3A; KIAA1356; NAC3; Nav1.3; Nav1.4; SCN4A; Nav1.5; SCN5A; Nav1.6; SCN8A; MED; Nav1.7; SCN9A; NENA; Nav1.8; SCN10A; Nav1.9; hNaN; SCN11A; SCN12A; SNS2
Gene Symbols SCN9A
Host Species Rabbit
Immunogen Recombit Human SCN9A
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6335
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only

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