Invitrogen™ SCNN1D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555451

Catalog No. PIPA555451

Description

Immunogen sequence: ELLDEFAREN IDSLYNVNLS KGRAALSATV PRHEPPFHLD REIRLQRLSH SGSRVRVGFR LCNSTGGDCF YRGYTSGVAA VQDWYHFHYV DILALLPAAW EDSHGSQDGH FVLSCSYDGL DCQARQFRTF HHPTYGSCYT VDG Highest antigen sequence identity to the following orthologs: Mouse - 26%, Rat - 25%.

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

Specifications

• Antigen: SCNN1D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCNN1D
• Gene Alias: Amiloride-sensitive sodium channel subunit delta; delta-ENaC; Delta-NaCH; DNACH; ENaCd; ENaCdelta; epithelial Na(+) channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; SCNN1D; sodium channel epithelial 1 delta subunit; sodium channel, non voltage gated 1 delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, voltage-gated, type I, delta polypeptide
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6339
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P51172
• Gene Symbols: SCNN1D
• Immunogen: Recombinant protein corresponding to Human SCNN1D. Recombinant protein control fragment (Product #RP-90378).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov