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Invitrogen™ SCNN1D Polyclonal Antibody
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Catalog No. PIPA555451
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100 μL
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PIPA555451 100 μL
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Catalog No. PIPA555451 Supplier Invitrogen™ Supplier No. PA555451
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELLDEFAREN IDSLYNVNLS KGRAALSATV PRHEPPFHLD REIRLQRLSH SGSRVRVGFR LCNSTGGDCF YRGYTSGVAA VQDWYHFHYV DILALLPAAW EDSHGSQDGH FVLSCSYDGL DCQARQFRTF HHPTYGSCYT VDG Highest antigen sequence identity to the following orthologs: Mouse - 26%, Rat - 25%.

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCNN1D
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SCNN1D
Gene Accession No. P51172
Gene Alias Amiloride-sensitive sodium channel subunit delta; delta-ENaC; Delta-NaCH; DNACH; ENaCd; ENaCdelta; epithelial Na(+) channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; SCNN1D; sodium channel epithelial 1 delta subunit; sodium channel, non voltage gated 1 delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, voltage-gated, type I, delta polypeptide
Gene Symbols SCNN1D
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SCNN1D. Recombinant protein control fragment (Product #RP-90378).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6339
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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