Invitrogen™ SCNN1D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587738

Catalog No. PIPA587738

Description

Immunogen sequence: GVEVELLHNT SYTRQACLVS CFQQLMVETC SCGYYLHPLP AGAEYCSSAR HPAWGHCFYR LYQDLETHRL PCTSRCPRPC RESAFKLSTG TSRWPSAKSA GWTLATLGEQ GLPHQSHRQR SSLAKINIVY QELNYRSVEE A; Positive Samples: U-87MG, A-549, MCF-7, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein.

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

Specifications

• Antigen: SCNN1D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCNN1D
• Gene Alias: Amiloride-sensitive sodium channel subunit delta; delta-ENaC; Delta-NaCH; DNACH; ENaCd; ENaCdelta; epithelial Na(+) channel subunit delta; MGC149710; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; SCNN1D; sodium channel epithelial 1 delta subunit; sodium channel, non voltage gated 1 delta subunit; sodium channel, nonvoltage-gated 1, delta; sodium channel, non-voltage-gated 1, delta subunit; sodium channel, voltage-gated, type I, delta polypeptide
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 103692528, 6339
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P51172
• Gene Symbols: SCNN1D
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 540-680 of human SCNN1D (NP_0011238852).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG