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SCNN1G Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501729108 Shop All Proteintech Group Inc Products
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50-172-9108 150 μL
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Catalog No. 50-172-9108 Supplier Proteintech Group Inc Supplier No. 139431AP150UL
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Description

Rabbit Polyclonal Antibody

Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel′s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Specifications

Antigen SCNN1G
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SCNN1G
Gene Accession No. P37091, P51170, Q9WU39
Gene Alias ENaCg, ENaCgamma, Gamma ENaC, Gamma NaCH, PHA1, SCNEG, SCNN1G
Gene Symbols SCNN1G
Host Species Rabbit
Immunogen SCNN1G Fusion Protein Ag5020
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20278, 24768, 6340
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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