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Invitrogen™ SCO1 Polyclonal Antibody
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Catalog No. PIPA544581
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100 μL
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PIPA544581 100 μL
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Catalog No. PIPA544581 Supplier Invitrogen™ Supplier No. PA544581
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Description

Rabbit Polyclonal Antibody

Peptide sequence: ALLAGMKHVK KEKAEKLEKE RQRHIGKPLL GGPFSLTTHT GERKTDKDYL Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Yeast: 91%.

Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCO1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SCO1
Gene Accession No. O75880
Gene Alias 2610001C07Rik; D11Bwg1310e; Protein SCO1 homolog, mitochondrial; RGD1559538; SCO cytochrome c oxidase assembly protein 1; SCO cytochrome oxidase deficient homolog 1; SCO cytochrome oxidase deficient homolog 1 (yeast); SCO1; SCO1 cytochrome c oxidase assembly protein; SCO1, cytochrome c oxidase assembly protein; SCOD1; synthesis of cytochrome C oxidase 1
Gene Symbols SCO1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human SCO1.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6341
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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