Invitrogen™ SCO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554460

Catalog No. PIPA554460

Description

Immunogen sequence: CPDVCPEELE KMIQVVDEID SITTLPDLTP LFISIDPERD TKEAIANYVK EFSPKLVGLT G Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.

Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.

Specifications

• Antigen: SCO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SCO1
• Gene Alias: 2610001C07Rik; D11Bwg1310e; Protein SCO1 homolog, mitochondrial; RGD1559538; SCO cytochrome c oxidase assembly protein 1; SCO cytochrome oxidase deficient homolog 1; SCO cytochrome oxidase deficient homolog 1 (yeast); SCO1; SCO1 cytochrome c oxidase assembly protein; SCO1, cytochrome c oxidase assembly protein; SCOD1; synthesis of cytochrome C oxidase 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6341
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75880
• Gene Symbols: SCO1
• Immunogen: Recombinant protein corresponding to Human SCO1. Recombinant protein control fragment (Product #RP-93315).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG