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Invitrogen™ SCO2 Polyclonal Antibody
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Catalog No. PIPA5100327
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100 μL
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PIPA5100327 100 μL
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Catalog No. PIPA5100327 Supplier Invitrogen™ Supplier No. PA5100327
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SCO2.

Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCO2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Sco2
Gene Accession No. O43819, Q8VCL2
Gene Alias CEMCOX1; MYP6; protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; SCO2; SCO2 cytochrome c oxidase assembly protein
Gene Symbols Sco2
Host Species Rabbit
Immunogen A synthesized peptide derived from human SCO2(Accession O43819), corresponding to amino acid residues R20-G70.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100126824, 9997
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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