Invitrogen™ SCO2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100327

Catalog No. PIPA5100327

Description

Antibody detects endogenous levels of total SCO2.

Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.

Specifications

• Antigen: SCO2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Sco2
• Gene Alias: CEMCOX1; MYP6; protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; SCO2; SCO2 cytochrome c oxidase assembly protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100126824, 9997
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43819, Q8VCL2
• Gene Symbols: Sco2
• Immunogen: A synthesized peptide derived from human SCO2(Accession O43819), corresponding to amino acid residues R20-G70.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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