Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA559221

Invitrogen™ SCUBE3 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA559221
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA559221 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA559221 Supplier Invitrogen™ Supplier No. PA559221
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Immunogen sequence: VLSIKQRASF KIKDAKCRLH LRNKGKTEEA GRITGPGGAP CSECQVTFIH LKCDSSRKGK GRRARTPPGK EVTRLTLELE AEVRAEETTA S Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 90%.

SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-Beta receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-Beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-Beta1, VEGF, Snail, and Slug.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCUBE3
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SCUBE3
Gene Accession No. Q8IX30
Gene Alias CEGF3; CUB domain and EGF-like repeat containing 3; D030038I21Rik; SCUBE3; signal peptide; signal peptide, CUB and EGF-like domain containing protein 3; signal peptide, CUB and EGF-like domain-containing protein 3; signal peptide, CUB domain and EGF like domain containing 3; signal peptide, CUB domain, EGF-like 3
Gene Symbols SCUBE3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SCUBE3. Recombinant protein control fragment (Product #RP-94883).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 222663
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.