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Invitrogen™ SDE2 Polyclonal Antibody
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Catalog No. PIPA5113986
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100 μL
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PIPA5113986 100 μL
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Catalog No. PIPA5113986 Supplier Invitrogen™ Supplier No. PA5113986
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AFTSVAELEL LGLEKLKCEL MALGLKCGGT LQERAARLFS VRGLAKEQID For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Goat: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Zebrafish: 100%.

Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SDE2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SDE2
Gene Accession No. Q6IQ49
Gene Alias C1orf55; dJ671D7.1; FLJ35382; protein SDE2 homolog; Replication stress response regulator SDE2; RGD1305572; SDE2; SDE2 telomere maintenance homolog; SDE2 telomere maintenance homolog (S. pombe); UPF0667 protein C1orf55; UPF0667 protein C1orf55 homolog
Gene Symbols SDE2
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C terminal region of human C1orf55 (aa 389-438).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 163859
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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