Invitrogen™ SDHB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529843

Catalog No. PIPA529843

Description

Recommended positive controls: NCI-H929, mouse brain. Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (90%), Xenopus laevis (93%), Dog (98%), Pig (98%), Chicken (90%), Rhesus Monkey (100%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Specifications

• Antigen: SDHB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Sdhb
• Gene Alias: 0710008N11Rik; CWS2; fj46d06; FLJ92337; I79_022285; Ip; iron-sulfur subunit; iron-sulfur subunit of complex II; OTTHUMP00000044624; PGL4; SDH; SDH1; SDH2; Sdhb; SDHB protein; SDHB; sdhB; SDHIP; succinate dehydrogenase [ubiquinone] iron-sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex iron sulfur subunit B; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex subunit B, iron sulfur (Ip); succinate dehydrogenase complex, subunit B, iron sulfur (Ip); succinate dehydrogenase Ip subunit; succinate dehydrogenase iron-protein subunit; wu:fj46d06
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 298596, 6390, 67680
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.42 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P21912, P21913, Q9CQA3
• Gene Symbols: Sdhb
• Immunogen: Recombinant fragment corresponding to a region within amino acids 66 and 280 of Human SDHB.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG