Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA561081

Invitrogen™ SDHD Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA561081
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA561081 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA561081 Supplier Invitrogen™ Supplier No. PA561081
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RTPVVRPAHI SAFLQDRPIP EWCGVQHIHL SPSHHSGSKA ASLHW Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 76%.

The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SDHD
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SDHD
Gene Accession No. O14521
Gene Alias 3110001M13Rik; AVLL5809; C78570; CBT1; CII-4; CWS3; CybS; PGL; PGL1; PRO19626; QPs3; SDH4; SDHD; Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex subunit D; succinate dehydrogenase complex subunit D integral membrane protein; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
Gene Symbols SDHD
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SDHD. Recombinant protein control fragment (Product #RP-100470).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6392
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.