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SDHD Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985802
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100 μL
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50-198-5802 100 μL
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Catalog No. 50-198-5802 Supplier Bioss Supplier No. BS3971R
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Description

Rabbit Polyclonal Antibody

The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

Specifications

Antigen SDHD
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SDHD
Gene Accession No. O14521
Gene Alias 3110001M13Rik; AVLL5809; C78570; CBT1; CII-4; CWS3; CybS; PGL; PGL1; PRO19626; QPs3; SDH4; Sdhd; Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Succinate dehydrogenase complex subunit D; succinate dehydrogenase complex subunit D integral membrane protein; succinate dehydrogenase complex, subunit D, integral membrane protein; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
Gene Symbols SDHD
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SDHD.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6392
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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