Invitrogen™ SDPR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA584530

Catalog No. PIPA584530

Description

Immunogen sequence: QHPGSDMRQE KPSSPSPMPS STPSPSLNLG NTEEAIRDNS QVNAVTVLTL LDKLVNMLDA VQENQHKMEQ RQISLEGSVK GIQNDLT.

The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

Specifications

• Antigen: SDPR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAVIN2
• Gene Alias: caveolae associated protein 2; caveolae-associated protein 2; cavin 2; CAVIN2; cavin-2; EMBL:AAH81956.1}; phosphatidylserine binding protein; phosphatidylserine-binding protein; PS-p68; SDPR; sdpr {ECO:0000312; SDR; serum deprivation response; serum deprivation response protein; serum deprivation-response protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8436
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95810
• Gene Symbols: CAVIN2
• Immunogen: Recombinant protein corresponding to Human CAVIN2. Recombinant protein control fragment (Product #RP-107133).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov