SDPRRabbit anti-Human, Polyclonal, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 600401J31

Catalog No. 50-199-2226

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-SDPR specific towards Cavin 2 SDR. A BLAST analysis was used to suggest cross-reactivity with Human based on 100% sequence homology. Cross-reactivity with SDPR from other sources has not been determined.

The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

Specifications

• Antigen: SDPR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CAVIN2
• Gene Alias: BOS_1929; caveolae associated protein 2; Caveolae-associated protein 2; cavin 2; CAVIN2; Cavin-2; EMBL:AAH81956.1}; phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS-p68; Sdpr; sdpr {ECO:0000312; Sdr; serum deprivation response; serum deprivation response protein; Serum deprivation-response protein
• Host Species: Rabbit
• Regulatory Status: RUO
• Gene ID (Entrez): 8436
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 1.02 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl, 50% glycerol and no preservative; pH 7.2
• Gene Accession No.: O95810
• Gene Symbols: CAVIN2
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody