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Invitrogen™ Securin Polyclonal Antibody
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Catalog No. 341500
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34-150-0 100 μg
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Catalog No. 34-150-0 Supplier Invitrogen™ Supplier No. 341500
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Description

Rabbit Polyclonal Antibody

Securin Polyclonal Antibody for Western Blot, IHC, ICC/IF, ELISA

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Securin
Applications ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Pttg1
Gene Accession No. O95997
Gene Alias AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1
Gene Symbols Pttg1
Host Species Rabbit
Immunogen Synthetic peptide derived from the transactivation domain within the N-terminus of the human PTTG-1 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9232
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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