Invitrogen™ Securin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 341500

Catalog No. 34-150-0

Description

Securin Polyclonal Antibody for Western Blot, ICC/IF, IHC, ELISA

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Specifications

• Antigen: Securin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pttg1
• Gene Alias: AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9232
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: O95997
• Gene Symbols: Pttg1
• Immunogen: Synthetic peptide derived from the transactivation domain within the N-terminus of the human PTTG-1 protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG