Invitrogen™ SELK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534420

Catalog No. PIPA534420

Description

A suggested positive control is A-20 cell lysate. PA5-34420 can be used with blocking peptide PEP-1462.

SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.

Specifications

• Antigen: SELK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SELENOK
• Gene Alias: 1110001C03Rik; AA673253; heat shock protein; heat shock protein, 30 kDa; Hsp30; HSPC030; HSPC297; Selenok; Selenoprotein K; SELK
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 290549, 58515, 80795
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P59798, Q9JLJ1, Q9Y6D0
• Gene Symbols: SELENOK
• Immunogen: An 18 amino acid synthetic peptide near the carboxy terminus of human SELK.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov