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Invitrogen™ SELK Polyclonal Antibody
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Catalog No. PIPA534420
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100 μg
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Catalog No. Quantity
PIPA534420 100 μg
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Catalog No. PIPA534420 Supplier Invitrogen™ Supplier No. PA534420
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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-34420 can be used with blocking peptide PEP-1462.

SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SELK
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SELENOK
Gene Accession No. P59798, Q9JLJ1, Q9Y6D0
Gene Alias 1110001C03Rik; AA673253; heat shock protein; heat shock protein, 30 kDa; Hsp30; HSPC030; HSPC297; Selenok; Selenoprotein K; SELK
Gene Symbols SELENOK
Host Species Rabbit
Immunogen An 18 amino acid synthetic peptide near the carboxy terminus of human SELK.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 290549, 58515, 80795
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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