Invitrogen™ SELK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552529

Catalog No. PIPA552529

Description

Immunogen sequence: KRRSYGNSSD SRYDDGRGPP GNPPRRMGRI NHLRGPS Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.

Specifications

• Antigen: SELK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SELENOK
• Gene Alias: 1110001C03Rik; AA673253; heat shock protein; heat shock protein, 30 kDa; Hsp30; HSPC030; HSPC297; Selenok; Selenoprotein K; SELK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 58515
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y6D0
• Gene Symbols: SELENOK
• Immunogen: Recombinant protein corresponding to Human SELK. Recombinant protein control fragment (Product #RP-88720).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG