Invitrogen™ SELK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578549

Catalog No. PIPA578549

Description

Positive Control: K562 Predicted Reactivity: Dog (97%), Pig (91%), Rabbit (89%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (89%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.

Specifications

• Antigen: SELK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SELENOK
• Gene Alias: 1110001C03Rik; AA673253; heat shock protein; heat shock protein, 30 kDa; Hsp30; HSPC030; HSPC297; Selenok; Selenoprotein K; SELK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 58515
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1.48 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q9Y6D0
• Gene Symbols: SELENOK
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SELK. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG