SELK Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 125611AP150UL

Catalog No. 50-172-8068

Description

SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited

Specifications

• Antigen: SELK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SELENOK
• Gene Alias: HSPC030, HSPC297, selenoprotein K, SELK
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 290549, 58515, 80795
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.15 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P59798, Q9JLJ1, Q9Y6D0
• Gene Symbols: Selenok
• Immunogen: SELK Fusion Protein Ag3143
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG