Invitrogen™ SEMA3C Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547189

Catalog No. PIPA547189

Description

In Western blots, less than 5% cross-reactivity with recombinant human (rh) Semaphorin 3A, rhSemaphorin 3B, rhSemaphorin 6A, recombinant mouse (rm) Semaphorin 3E, rmSemaphorin 3F, rmSemaphorin 6A, and rmSemaphorin 7A is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The SEMA3C gene encodes the protein semaphorin 3C, a member of the semaphorin family known for its roles in axonal guidance, cellular signaling, and vascular development. Semaphorin 3C is involved in guiding neurons during development by serving as a repulsive cue, helping establish proper neural network formation through interaction with neuropilin and plexin receptors. It also plays crucial roles in angiogenesis and cardiac development by influencing endothelial cell behavior and migration. In the context of cancer, SEMA3C is implicated in tumor progression, where its dysregulation can promote tumor cell invasion and metastasis by modifying the extracellular matrix and affecting cellular adhesion. Research has demonstrated that SEMA3C can alter the tumor microenvironment, making it a potential target for cancer therapies aimed at inhibiting metastasis and controlling tumor growth. Understanding SEMA3C's function in various biological processes continues, highlighting its significance in developmental biology and disease modulation.

Specifications

• Antigen: SEMA3C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEMA3C
• Gene Alias: 1110036B02Rik; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; sema E; Sema3c; Semae; semaphorin 3C; semaphorin E; semaphorin-3C; Semaphorin-E; SemE
• Host Species: Sheep
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20348
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q62181
• Gene Symbols: SEMA3C
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Semaphorin 3C Gln24-Ser751 (Arg48Ala, Arg52Ala).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov