Invitrogen™ SEMA3E Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547469

Catalog No. PIPA547469

Description

In direct ELISAs, approximately 30% cross-reactivity with recombinant mouse (rm) Semaphorin 3E is observed and less than 10% cross-reactivity with rmSemaphorin 3A, rmSemaphorin 3B, rmSemaphorin 3C, rmSemaphorin 3F, and recombinant human (rh) Semaphorin 3A, rhSemaphorin 3C, rhSemaphorin 3D, and rhSemaphorin 3F is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved approximately 400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.

Specifications

• Antigen: SEMA3E
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEMA3E
• Gene Alias: 6430702L12; AA408817; coll-5; KIAA0331; mKIAA0331; M-sema H; M-SEMAH; M-SemaK; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; sema H; Sema3e; SEMAH; semaphorin 3E; semaphorin-3E; Semaphorin-H; Semh
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20349, 9723
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O15041, P70275
• Gene Symbols: SEMA3E
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Semaphorin 3E Thr25-Ser775 (Arg557Ala and Arg560Ala).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG