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Invitrogen™ SEMA4G Polyclonal Antibody
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Catalog No. PIPA547786
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100 μg
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PIPA547786 100 μg
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Catalog No. PIPA547786 Supplier Invitrogen™ Supplier No. PA547786
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Description

Sheep Polyclonal Antibody

In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse (rm) Semaphorin 4G is observed and less than 1% cross reactivity with recombinant human (rh) Semaphorin 3B, rhSemaphorin 4A, and rhSemaphorin 4C is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The SEMA4G gene encodes semaphorin 4G, a member of the semaphorin protein family known for their roles in cellular guidance, signaling, and development. Semaphorin 4G is involved in axonal guidance, where it influences the direction and growth of neurons by interacting with receptor complexes such as plexins. This interaction is critical in neural development, contributing to the proper formation of neural circuits by ensuring that neurons connect accurately and functionally. Beyond its role in the nervous system, SEMA4G also participates in immune responses, where it modulates the activity and migration of immune cells, influencing processes like inflammation and immune surveillance. This protein's modulation of cell-to-cell communication and migration extends to its implications in cancer, where altered semaphorin signaling can impact tumor progression and metastasis through changes in cell adhesion and migration properties. Research into SEMA4G continues to investigate its precise mechanisms and interactions, providing insights into therapeutic opportunities in neural disorders and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SEMA4G
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene SEMA4G
Gene Accession No. Q9NTN9
Gene Alias AI507908; AW554132; KIAA1619; KIAA1619FLJ20590; MGC102867; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G; Sema4g; semaphorin 4G; semaphorin-4G
Gene Symbols SEMA4G
Host Species Sheep
Immunogen Mouse myeloma cell line NS0-derived recombinant human Semaphorin 4G Val18-Leu675.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57715
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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