Invitrogen™ SEMA4G Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547786

Catalog No. PIPA547786

Description

In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse (rm) Semaphorin 4G is observed and less than 1% cross reactivity with recombinant human (rh) Semaphorin 3B, rhSemaphorin 4A, and rhSemaphorin 4C is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The SEMA4G gene encodes semaphorin 4G, a member of the semaphorin protein family known for their roles in cellular guidance, signaling, and development. Semaphorin 4G is involved in axonal guidance, where it influences the direction and growth of neurons by interacting with receptor complexes such as plexins. This interaction is critical in neural development, contributing to the proper formation of neural circuits by ensuring that neurons connect accurately and functionally. Beyond its role in the nervous system, SEMA4G also participates in immune responses, where it modulates the activity and migration of immune cells, influencing processes like inflammation and immune surveillance. This protein's modulation of cell-to-cell communication and migration extends to its implications in cancer, where altered semaphorin signaling can impact tumor progression and metastasis through changes in cell adhesion and migration properties. Research into SEMA4G continues to investigate its precise mechanisms and interactions, providing insights into therapeutic opportunities in neural disorders and cancer.

Specifications

• Antigen: SEMA4G
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEMA4G
• Gene Alias: AI507908; AW554132; KIAA1619; KIAA1619FLJ20590; MGC102867; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G; Sema4g; semaphorin 4G; semaphorin-4G
• Host Species: Sheep
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57715
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9NTN9
• Gene Symbols: SEMA4G
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Semaphorin 4G Val18-Leu675.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG