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Invitrogen™ SEMA6B Polyclonal Antibody
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Catalog No. PIPA563176
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100 μL
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PIPA563176 100 μL
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Catalog No. PIPA563176 Supplier Invitrogen™ Supplier No. PA563176
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AGTVLKFLVR PNASTSGTSG LSVFLEEFET YRPDRCGRPG GGETGQRLLS LELDAASGGL LAAFPRCVVR VPVARCQQYS GCMKNCIG Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 87%.

The SEMA6B gene encodes semaphorin 6B, which belongs to the semaphorin family of proteins known for their roles in guiding axonal development and modulating cellular signaling pathways. Semaphorin 6B primarily functions in the nervous system where it influences axonal guidance, neuronal development, and synapse formation through interactions with neuropilin and plexin receptor complexes. These interactions are crucial during neural development, ensuring proper neuronal wiring and the establishment of functional neural circuits. In addition to its key role in neural connectivity, SEMA6B is increasingly recognized for its involvement in immune responses, where it can modulate the activity and migration of immune cells. In cancer biology, altered expression of SEMA6B has been implicated in tumor progression, affecting tumor cell adhesion and migration, thereby influencing metastasis. Research continues to explore the specific mechanisms of SEMA6B's action and how it can be targeted for therapeutic interventions in neural and cancer-related diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SEMA6B
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SEMA6B
Gene Accession No. Q9H3T3
Gene Alias Sema; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; sema N; Sema VIB; sema Z; SEMA6B; SEMAN; semaphorin 6B; semaphorin VIB; semaphorin Z; semaphorin-6B; semaphorin-6Ba; semaphorin-N; Semaphorin-Z; SEMA-VIB; semaZ; SEM-SEMA-Y; UNQ1907/PRO4353; VIb
Gene Symbols SEMA6B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SEMA6B. Recombinant protein control fragment (Product #RP-103230).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10501
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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