Invitrogen™ SEMA6B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563581

Catalog No. PIPA563581

Description

Immunogen sequence: DYLNHYPVFV GSGPGRLTPA EGADDLNIQR VLRVNRTLFI GDRDNLYRVE LEPPTSTELR YQRKLTWRSN PSDINVCRMK GKQEGECRNF VKVLL Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

The SEMA6B gene encodes semaphorin 6B, which belongs to the semaphorin family of proteins known for their roles in guiding axonal development and modulating cellular signaling pathways. Semaphorin 6B primarily functions in the nervous system where it influences axonal guidance, neuronal development, and synapse formation through interactions with neuropilin and plexin receptor complexes. These interactions are crucial during neural development, ensuring proper neuronal wiring and the establishment of functional neural circuits. In addition to its key role in neural connectivity, SEMA6B is increasingly recognized for its involvement in immune responses, where it can modulate the activity and migration of immune cells. In cancer biology, altered expression of SEMA6B has been implicated in tumor progression, affecting tumor cell adhesion and migration, thereby influencing metastasis. Research continues to explore the specific mechanisms of SEMA6B's action and how it can be targeted for therapeutic interventions in neural and cancer-related diseases.

Specifications

• Antigen: SEMA6B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEMA6B
• Gene Alias: Sema; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; sema N; Sema VIB; sema Z; SEMA6B; SEMAN; semaphorin 6B; semaphorin VIB; semaphorin Z; semaphorin-6B; semaphorin-6Ba; semaphorin-N; Semaphorin-Z; SEMA-VIB; semaZ; SEM-SEMA-Y; UNQ1907/PRO4353; VIb
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10501
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H3T3
• Gene Symbols: SEMA6B
• Immunogen: Recombinant protein corresponding to Human SEMA6B. Recombinant protein control fragment (Product #RP-103334).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov