Invitrogen™ SENP5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531063

Catalog No. PIPA531063

Description

Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7. Predicted reactivity: Mouse (97%), Xenopus laevis (82%), Rhesus Monkey (80%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the GG region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.

Specifications

• Antigen: SENP5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SENP5
• Gene Alias: 6230429P13Rik; A730063F07Rik; AI851888; BB189556; DKFZp564O1016; FKSG45; FLJ42398; MGC27076; Senp5; sentrin/SUMO-specific protease SENP5; Sentrin-specific protease 5; SMT3IP3; SUMO/sentrin specific peptidase 5; SUMO/sentrin specific protease 5; SUMO/Smt3-specific isopeptidase 3; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5; Sumo1/sentrin/SMT3 specific peptidase 5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 205564
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96HI0
• Gene Symbols: SENP5
• Immunogen: Recombinant fragment corresponding to a region within amino acids 437 and 752 of Human SENP5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG