Invitrogen™ SENP6 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518881

Catalog No. PIPA518881

Description

This antibody is predicted to react with mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Ubiquitin-like molecules, such as SUMO1, are structurally related to ubiquitin. and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1. to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.

Specifications

• Antigen: SENP6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SENP6
• Gene Alias: 2810017C20Rik; E130319N12Rik; FKSG6; FLJ11355; FLJ11887; KIAA0389; KIAA0797; mKIAA0797; RP1-134M13.1; SENP6; sentrin/SUMO-specific protease SENP6; Sentrin-specific protease 6; Sentrin-specific protease 6-like protein; SSP1; SUMO specific peptidase 6; SUMO/sentrin specific peptidase 6; SUMO/sentrin specific protease 6; SUMO1/sentrin specific peptidase 6; SUMO1/sentrin specific protease 6; Sumo1/sentrin/SMT3 specific peptidase 6; SUMO-1-specific protease 1; Susp1
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 26054
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9GZR1
• Gene Symbols: SENP6
• Immunogen: Synthetic peptide sequence (KPKYEPNPHYHEN) corresponding to the internal amino acids of SENP6 (aa 778-791).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG