SENP8 Mouse anti-Human, Clone: OTI3E4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF804753

Catalog No. 50-166-7118

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Principal Names: Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8; Official Gene Symbol: SENP8 Gene ID: 123228 (Human) Gene Map Locus: 15q23 (Human) SENP8, is a novel cysteine protease which belongs to the ULP family of deubiquitinases. ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity. SENP8, a 24KDa protein, plays a major role in regulating NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may play a role in preventing accumulation of hyper-neddylated cullin and maintaining the level of mono-neddylated cullin that is thought to increase the efficiency of ubiquitination by SCF ubiquitin ligases.

Specifications

• Antigen: SENP8
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SENP8
• Gene Alias: DEN1, NEDP1, PRSC2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 123228
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3E4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96LD8
• Gene Symbols: SENP8
• Immunogen: Full length human recombit protein of human SENP8 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1