Invitrogen™ SENP8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531033

Catalog No. PIPA531033

Description

Recommended positive controls: 293T. Predicted reactivity: Human (99%), Mouse (91%), Rat (92%), Rhesus Monkey (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8), is a novel cysteine protease which belongs to the ULP family of deubiquitinases. ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity. SENP8, a 24KDa protein, plays a major role in regulating NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may play a role in preventing accumulation of hyper-neddylated cullin and maintaining the level of mono-neddylated cullin that is thought to increase the efficiency of ubiquitination by SCF ubiquitin ligases.

Specifications

• Antigen: SENP8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Senp8
• Gene Alias: 9130010J17Rik; AU020827; DEN1; deneddylase 1; deneddylase-1; FKSG8; NEDD8 specific-protease cysteine 2; NEDD8-specific protease 1; Nedp1; protease, cysteine 2; protease, cysteine, 2 (NEDD8 specific); PRSC2; SENP8; sentrin/SUMO-specific protease SENP8; Sentrin-specific protease 8; SUMO sentrin specific protease family member 8; SUMO/sentrin peptidase family member, NEDD8 specific; SUMO/sentrin specific peptidase 8; SUMO/sentrin specific peptidase family member 8; SUMO/sentrin specific protease 8; SUMO/sentrin specific protease family member 8; Sumo1/sentrin/SMT3 specific peptidase 8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 123228
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96LD8
• Gene Symbols: Senp8
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 200 of Human SENP8.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG