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Invitrogen™ SENP8 Polyclonal Antibody
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Catalog No. PA549754
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100 μL
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PA549754 100 μL
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Catalog No. PA549754 Supplier Invitrogen™ Supplier No. PA549754
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total SENP8 protein.

SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8), is a novel cysteine protease which belongs to the ULP family of deubiquitinases. ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity. SENP8, a 24KDa protein, plays a major role in regulating NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may play a role in preventing accumulation of hyper-neddylated cullin and maintaining the level of mono-neddylated cullin that is thought to increase the efficiency of ubiquitination by SCF ubiquitin ligases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SENP8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Senp8
Gene Accession No. Q5FVJ8, Q96LD8, Q9D2Z4
Gene Alias 9130010J17Rik; AU020827; DEN1; deneddylase 1; deneddylase-1; FKSG8; NEDD8 specific-protease cysteine 2; NEDD8-specific protease 1; Nedp1; protease, cysteine 2; protease, cysteine, 2 (NEDD8 specific); PRSC2; SENP8; sentrin/SUMO-specific protease SENP8; Sentrin-specific protease 8; SUMO sentrin specific protease family member 8; SUMO/sentrin peptidase family member, NEDD8 specific; SUMO/sentrin specific peptidase 8; SUMO/sentrin specific peptidase family member 8; SUMO/sentrin specific protease 8; SUMO/sentrin specific protease family member 8; Sumo1/sentrin/SMT3 specific peptidase 8
Gene Symbols Senp8
Host Species Rabbit
Immunogen Synthesized peptide derived from Internal of human SENP8.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 123228, 315723, 71599
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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