Invitrogen™ SEP15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103009

Catalog No. PIPA5103009

Description

Antibody detects endogenous levels of total SEP15.

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Specifications

• Antigen: SEP15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Selenof
• Gene Alias: 15 kDa selenoprotein; 15 kDa selenoprotein isoform 1 precursor; 15 kDa selenoprotein SeP15; 15kDa selenoprotein; 15-kDa selenoprotein; 15-Sep; 9430015P09Rik; cb29; Selenof; selenoprotein; selenoprotein 15; selenoprotein F; Sep15; sep15 protein; si:dkey-43b14.10; zgc:86882
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 113922, 9403
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O60613, Q923V8
• Gene Symbols: Selenof
• Immunogen: A synthesized peptide derived from human SELENOF(Accession O60613), corresponding to amino acid residues E35-L63.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov