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SEPN1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550752

Catalog No. PA550752


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Description

Description

The antibody detects endogenous levels of total SEPN1 protein.

SEPN1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Mutations in SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3 ft. UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Specifications

Specifications

SEPN1
Polyclonal
Unconjugated
SELENON
Liquid
SELENON
Synthetic peptide corresponding to a region derived from internal residues of human selenoprotein N, 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
0.5 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9NZV5
SELN
Rabbit
IgG
100 μL
-20°C
Primary
57190
Documents
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