SEPT2 Recombinant Rabbit Monoclonal Antibody (JB41-30), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Thermo Scientific MA534651

Catalog No. PIMA534651

Description

Positive Control: Mouse brain, K562, SHSY-5Y, HUVEC, HepG2, human colon cancer tissue, human kidney tissue, rat brain tissue.

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.

Specifications

• Antigen: SEPT2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q15019
• Gene Symbols: SEPTIN2
• Immunogen: Recombinant protein within Human Septin 2 aa 182-318
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: JB41-30
• Conjugate: Unconjugated
• Gene: SEPTIN2
• Gene Alias: 2-Sep; AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD5; Nedd-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Pnutl3; Sept2; septin 2; Septin2; septin-2; Vascular endothelial cell specific protein 11; Vesp11
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4735
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov