Invitrogen™ SEPT5 Chimeric Recombinant Rabbit Monoclonal Antibody (SP18)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA547888

Catalog No. PIMA547888

Description

Specificity: This antibody recognises CDCrel-1 and does not cross-react with CDCrel-2.

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.

Specifications

• Antigen: SEPT5 Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: Q99719, Q9JJM9
• Gene Symbols: SEPTIN5
• Immunogen: Immunoprecipitate from human brain.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat, Rabbit
• Product Type: Antibody
• Isotype: IgG κ

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: SP18
• Conjugate: Unconjugated
• Gene: SEPTIN5
• Gene Alias: 5-Sep; CDCREL; CDCREL1; CDCREL-1; CDCrel-1A; cell division control related protein 1; cell division control-related protein 1; H5; HCDCREL-1; peanut-like 1; peanut-like 1 homolog; peanut-like protein 1; platelet glycoprotein Ib beta chain; Pnutl1; Sept5; septin 5; SEPTIN5; septin-5
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 116728, 5413
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid