Invitrogen™ SEPT5 Monoclonal Antibody (SP18), FITC

Catalog No.	Quantity
PIMA517620	100 μg

Catalog No. PIMA517620 Supplier Invitrogen™ Supplier No. MA517620

Description

Mouse Monoclonal Antibody

MA5-17620 targets SEPT5/CDCre-1 in FACS applications and shows reactivity with Human samples. The MA5-17620 immunogen is human CDCrel-1/SEPT5.

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.

Specifications

• Antigen: SEPT5
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: SP18
• Concentration: 0.1 mg/mL
• Conjugate: FITC
• Formulation: PBS with 4-5mg/mL BSA and 0.02% sodium azide
• Gene: SEPTIN5
• Gene Accession No.: Q99719
• Gene Alias: 5-Sep; CDCREL; CDCREL1; CDCREL-1; CDCrel-1A; cell division control related protein 1; cell division control-related protein 1; H5; HCDCREL-1; peanut-like 1; peanut-like 1 homolog; peanut-like protein 1; platelet glycoprotein Ib beta chain; Pnutl1; Sept5; septin 5; SEPTIN5; septin-5
• Gene Symbols: SEPTIN5
• Host Species: Mouse
• Immunogen: Human CDCrel-1/SEPT5.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5413
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1