Invitrogen™ SEPT5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104122

Catalog No. PIPA5104122

Description

Antibody detects endogenous levels of total SEPT5.

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.

Specifications

• Antigen: SEPT5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SEPTIN5
• Gene Alias: 5-Sep; CDCREL; CDCREL1; CDCREL-1; CDCrel-1A; cell division control related protein 1; cell division control-related protein 1; H5; HCDCREL-1; peanut-like 1; peanut-like 1 homolog; peanut-like protein 1; platelet glycoprotein Ib beta chain; Pnutl1; Sept5; septin 5; SEPTIN5; septin-5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116728, 18951, 5413
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q99719, Q9JJM9, Q9Z2Q6
• Gene Symbols: SEPTIN5
• Immunogen: A synthesized peptide derived from human SEPT5(Accession Q99719), corresponding to amino acid residues R207-G257.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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